DNABinding Motifs in Gene Regulatory Proteins
In either case, two α helices that extend from the dimerization interface make specific contacts with the DNA. Figure 725. A helixloophelix dimer bound to DNA. The two monomers are held together in a fourhelix bundle: each monomer contributes two α helices connected by a flexible loop of protein (red). A specific DNA sequence is bound by the two α helices . Several HLH proteins lack the ...